This article reviews 11 health benefits of mangosteen and how to eat it. An herbal formulation containing extracts obtained from mangosteen and Sphaeranthus indicus has been evaluated for weight loss; however, attributing positive findings to either of the individual constituent extracts is difficult. α-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis. Here are some of the xanthones in mangosteen: In terms of direct studies on cancer, the following quote is related to cancer: We found that antiproliferative effect of CME [crude methanolic extract] was associated with apoptosis on breast cancer cell line by determinations of morphological changes and oligonucleosomal DNA fragments. Case Report: Severe lactic acidosis following consumption of mangosteen juice daily for 12 months. Preliminary data show that xanthones, bioactive compounds in mangosteen, exhibit antibacterial (3), antifungal (4), anti-inflammatory (5), antiatherosclerotic (7), anti-asthmatic (26), antiangiogenic (27), cytotoxic (12), aromatase-inhibitory (14), and anticancer (17) (18) properties. As of April 2013, it also states that the mangosteen "fruit has been shown to be rich in anti-oxidants. Mangosteen is said to have a wide range of benefits, most result from its xanthone phytoceuticals/antioxidants. Efficacy and tolerability of an herbal formulation for weight management. And that can be even better than eating the fruit. Clinical relevance is not known. Mangosteen has gained worldwide popularity in recent years and is available on the Internet and in health food stores. Small clinical studies suggest benefits of mangosteen-containing products as adjuncts in periodontal treatment (20); controlling halitosis (21); and in the treatment of chronic periodontitis (44). The Effect of Gartanin, a Naturally Occurring Xanthone in Mangosteen Juice, on the mTOR Pathway, Autophagy, Apoptosis, and the Growth of Human Urinary Bladder Cancer Cell Lines Article Oct 2013 I am sold too and have just ordered my first bottles. However, these are not the only properties in the berry and juice that can help you live a healthier life. all of the treatments their physicians urged them to undergo. This juice is also considered as a good treatment for diabetics. It reduced matrix metalloproteinase MMP-2 and -9 expression, increased E-cadherin expression, and suppressed the ERK signaling pathway in pancreatic cancer cell lines (36). (to protect DNA), antioxidantsProtects cells from damage caused by free radicals (unstable molecules made by the process of oxidation during normal metabolism). “Garcinone E, a Xanthone Derivative, has Potent Cytotoxic Effect Against Hepatocellular Carcinome Cell Lines” by Chi-Kuan Ho, Yu-Ling Huang and Chieh-Chih Chen. Mangosteen juice is marketed as a health drink and the pericarp, or fruit hull, is used in dietary supplements for its antioxidant activity. Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana. Small clinical studies suggest benefits of mangosteen-containing products as adjuncts in periodontal treatment; controlling halitosis; and in the treatment of chronic periodontitis. Also called programmed cell death. alpha-Mangostin extracted from the pericarp of the mangosteen (, Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of, Effects of herbal mouthwash containing the pericarp extract of. Extracts from the pericarp of mangosteen also exhibit antioxidant (13), antiproliferative, and apoptotic effects (11). Most people won't eat that. American Cancer Society, in lab studies mangosteen has slowed down the growth of certain cancer cells. Acute Garcinia mangostana (mangosteen) supplementation does not alleviate physical fatigue during exercise: a randomized, double-blind, placebo-controlled, crossover trial. One particular xanthone called "garcenone-E", has shown to be a more-effective cancer fighter than five of the six potent cemo-therapy drugs. Overview Information Mangosteen is a plant used to make medicine. All xanthones displayed growth inhibitory effects. Mangosteen juice typically contains xanthones which helps to lower the risk of cancer. I like to use mangosteen juice to make vinaigrette for salads. Thus, it indicates that this substance can show different activities and has potential for cancer chemoprevention which were dose dependent as well as exposure time dependent. It may promote diarrhoea, gastric reflux and bloating. And I pray for you guys...I go back to the dr in February for all my tests. Lynn . Another study also attributes the antitumor activity of alpha-mangostin to autophagy and not endoplasmic reticulum stress induction (24). Dietary alpha-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice. Using mangosteen juice 1 hour before exercise does n't seem to improve how tired the muscles get exercise. Part in cancer cells it a possible complementary medicine, out of the whole fruit is juiced get! Treated with alpha-mangostin extracted from mangosteen induces anti-inflammatory and immunosuppressant effects in animal models 30. Cancer: the pericarp of mangosteen juice has n't been studied thoroughly another study attributes. Thus making it a possible complementary medicine … mangosteen is a unique, tropical, sweet-and-sour that! ( 47 ), ripe mango and ripe papaya—on murine hepatic cytochrome P450 activities it also states that the juice... 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